Most follow speculative fiction themes of fantasy, science fiction, and horror. McGuire has published filk music, poetry, short fiction, essays, and novels. She has autism, which she was diagnosed with in 2020, attention deficit hyperactivity disorder and obsessive–compulsive disorder, diagnosed when she was nine. She identifies as pansexual, bisexual, and demisexual and writes numerous queer characters into her work. Before becoming a full-time writer, she worked at a reptile rescue organization. McGuire frequently posts online about roleplaying games, My Little Pony, and caring for her menagerie of cats. She has described her interests as including 'swamps, long walks, long walks in swamps, things that live in swamps, horror movies, strange noises, musical theater, reality TV, comic books, finding pennies on the street, and venomous reptiles.' McGuire was born in California and attended University of California, Berkeley.

In 2013, McGuire received a record five Hugo nominations in total, two for works as Grant and three under her own name. Her 2016 novella Every Heart a Doorway received a Nebula Award, Hugo Award, Locus Award, and Alex Award.

Campbell Award for Best New Writer by the World Science Fiction Convention. Deborah Baker to write the 'Up-and-Under' children's portal fantasy series. She uses the pseudonym Mira Grant to write science fiction/ horror and the pseudonym A. McGuire is known for her urban fantasy novels.

Seanan McGuire (pronounced SHAWN-in born January 5, 1978, in Martinez, California) is an American author and filker.

Locus Award for Best Fantasy Novel (2020).

Campbell Award for Best New Writer (2010) “ Feed is a proper thriller with zombies. McGuire has crafted a masterpiece of suspense with engaging, appealing characters who conduct a soul-shredding examination of what's true and what's reported.'― Publishers Weekly (Starred Review) 'It's a novel with as much brains as heart, and both are filling and delicious.'― The A. With too much left to do and not much time left to do it, the surviving staff of After the End Times must face mad scientists, zombie bears, rogue government agencies-and if there's one thing they know is true in post-zombie America, it's this:

Now, the year is 2041, and the investigation that began with the election of President Ryman is much bigger than anyone had assumed. They uncovered the biggest conspiracy since the Rising and realized that to tell the truth, sacrifices have to be made. Georgia and Shaun Mason set out on the biggest story of their generation. The world didn't end when the zombies came, it just got worse. The explosive conclusion to the Newsflesh trilogy from New York Times bestseller Mira Grant - a saga of zombies, geeks, politics, social media, and the virus that runs through them all.

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